The MFQ assesses recent self-reported depressive symptoms on a 4-point scale (never, sometimes, often, and always), with total scores ranging from 0 to 66 (higher scores indicate more severe depressive symptoms). Patients with depression completed the 33-item Mood and Feelings Questionnaire (MFQ) prior to treatment, with regular additional assessments up to 12 months after the end of treatment (ie, mean, 22 months after baseline assessment). ![]() We tested whether network characteristics at baseline were prognostic for long-term outcomes. Here, we performed a conceptual replication of that study in adolescents with depression who participated in a psychological treatment trial. An influential naturalistic study by van Borkulo et al published in JAMA Psychiatry 3 reported that adult patients with depression who continue to experience problems in subsequent years have more densely connected networks at baseline than patients who later recover. 3 Intuitively, one may expect that more densely connected networks would be more inclined to result in negative spirals (eg, sleeplessness causes an individual to be too tired to go out, which leads to a lack of friends, resulting in sadness) and therefore more liable to nonresponse. 2 It has been suggested that the network structure of depressive symptoms (ie, group-level covariance or connectivity between symptoms) may be informative in this regard. 1 Prognostic markers to identify this nonresponder group are lacking and urgently needed. One in 4 adolescents with depression does not respond favorably to treatment.
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